Automated Surgical Intervention Support Tool for Traumatic Brain Injury (ASIST-TBI)
2025-11-30https://doi.org/10.1148/atlas.1764460229714
153
Overview
Schema Version
https://atlas.rsna.org/schemas/2025-11/model.json
Name
Automated Surgical Intervention Support Tool for Traumatic Brain Injury (ASIST-TBI)
Link
https://doi.org/10.1148/ryai.230088
Indexing
Keywords: CT, Brain/Brain Stem, Surgery, Trauma, Prognosis, Classification, Traumatic Brain Injury, Triage, Machine Learning, Decision Support
Content: CT, ER, NR
Author(s)
Christopher W. Smith
Armaan K. Malhotra
Christopher Hammill
Derek Beaton
Erin M. Harrington
Yingshi He
Husain Shakil
Amanda McFarlan
Blair Jones
Hui Ming Lin
François Mathieu
Avery B. Nathens
Alun D. Ackery
Garrick Mok
Muhammad Mamdani
Shobhit Mathur
Jefferson R. Wilson
Robert Moreland
Errol Colak
Christopher D. Witiw
Organization(s)
St Michael's Hospital
Unity Health Toronto, Li Ka Shing Knowledge Institute
Unity Health Toronto, Data Science and Advanced Analytics
University of Toronto, Temerty Faculty of Medicine
University of Toronto, Institute for Health Policy, Management and Evaluation
University of Toronto, Interdepartmental Division of Critical Care
University of Toronto, Leslie Dan Faculty of Pharmacy
Sunnybrook Health Sciences Centre, Division of Trauma Surgery
Version
1.0
License
Text: © 2024 by the Radiological Society of North America, Inc.
URL: https://pubs.rsna.org/doi/10.1148/ryai.230088
Contact
ot.htlaehytinu@witiW.rehpotsirhC
Funding
Supported by St Michael's Hospital Medical Services Association Innovation Fund. E.C. supported by the Odette Professorship in Artificial Intelligence for Medical Imaging, St Michael's Hospital, Unity Health Toronto.
Ethical review
Institutional research ethics board approval was obtained; informed consent was waived due to impracticality, minimal risk, and safeguards in place.
Date
Published: 2024-01-10
References
[1] Smith CW, Malhotra AK, Hammill C, et al.. "Vision Transformer–based Decision Support for Neurosurgical Intervention in Acute Traumatic Brain Injury: Automated Surgical Intervention Support Tool". Radiology: Artificial Intelligence. 2024;6(2):e230088. 2024-01-10. doi:10.1148/ryai.230088. PMID: 38197796. PMCID: PMC10982820.
Model
Architecture
Vision Transformer-based model: CT scans split into fixed-size 1D patches with learnable spatial embeddings, passed through a transformer encoder (pretrained weights frozen), followed by a multilayer perceptron binary classification head.
Availability
Not publicly released; data provided by third parties (Ontario Trauma Registry, Unity Health Toronto).
Clinical benefit
Predicts need for acute neurosurgical intervention from initial trauma head CT to support triage and interfacility transfer prioritization, potentially improving resource allocation and patient care.
Clinical workflow phase
patients’ triage; clinical decision support systems.
Decision threshold
Binary decision obtained by thresholding the classifier output; specific threshold not reported.
Degree of automation
Assists clinician decision-making (decision support); does not automate clinical decisions.
Indications for use
Adults (≥18 years) presenting with acute traumatic brain injury undergoing noncontrast head CT in emergency/trauma settings to assess likelihood of neurosurgical intervention within 72 hours.
Input
Preprocessed noncontrast head CT scans (NIfTI after DICOM conversion; registered to a standard head CT template).
Instructions
Apply to acute, preoperative, noncontrast trauma head CT scans with adequate image quality; exclude postoperative, contrast-enhanced, duplicate navigation, and nondiagnostic motion scans; trained for adults ≥18 years; predictions pertain to interventions within 72 hours of scan acquisition.
Limitations
Single-center development and testing with scans from a single CT manufacturer; potential bias from surgeon-level decision making in the ground truth; 72-hour intervention label may miss delayed interventions; misclassifications noted in cases with low GCS and small-volume hemorrhage (ICP monitoring), cases later exhibiting hemorrhage expansion, depressed/open skull fractures, and cases with large hemorrhages but DNR/poor neurologic status; fairness testing showed no significant differences by age or sex but lower GCS among misclassified cases; external validation pending.
Output
CDEs: RDE2278, RDE2279, RDE1791.4, RDE1981.2, RDE1981
Description: Binary classification indicating whether neurosurgical intervention will be required within 72 hours of the acute trauma head CT.
Recommendation
Use as an adjunct for triage and decision support to prioritize transfers and neurosurgical consultation in acute TBI; clinical judgment and guidelines should prevail, especially in severe TBI with established care pathways.
Reproducibility
Preprocessing and model architecture described; pretrained transformer encoder with frozen weights; additional training parameters provided in Appendix S1; code and model weights not provided.
Use
Intended: Decision support, Triage
Out-of-scope: Prognosis, Decision support
Excluded: Decision support
User
Intended: Referring provider, Physician, Radiologist, Other